Research Blog

Evidence-Based Research Articles

Mechanism deep-dives, compound comparisons, dosing protocols, and Q&A — all referenced to peer-reviewed literature. 28 articles published.

Peptides

15 articles

Deep DiveMay 29, 2026

PT-141 (Bremelanotide): Sexual Function Research Review

PT-141 mechanism and efficacy: how bremelanotide activates melanocortin receptors in the brain, what Phase III female HSDD trials showed, and why male ED dev...

Peptides8 min read

Deep DiveMay 29, 2026

Epithalon for Longevity: Reviewing the Evidence on Telomerase

Epithalon mechanism and research review: how this tetrapeptide activates telomerase in cell culture, what rodent lifespan studies show, and where human data ...

Peptides7 min read

Deep DiveMay 28, 2026

What Is VIP Peptide? Vasoactive Intestinal Peptide Research Overview

VIP peptide mechanism and research: how this 28-amino acid neuropeptide signals through VPAC receptors, what rodent and human trials show, and clinical barri...

Peptides8 min read

Deep DiveMay 28, 2026

What Is Sermorelin? The GHRH Analogue for Growth Hormone Research

Sermorelin mechanism and research: how this GHRH analogue stimulates natural GH release, what clinical trials show, and where the evidence gaps remain.

Peptides8 min read

Deep DiveMay 28, 2026

Tirzepatide Half-Life and Weekly Dosing: The Pharmacokinetics Explained

Tirzepatide half-life explained: 5-day elimination kinetics, weekly dosing schedule, steady-state pharmacokinetics, and how albumin binding extends duration.

Peptides8 min read

Deep DiveMay 28, 2026

Tesamorelin for Visceral Fat: What Phase 3 Clinical Trials Found

Tesamorelin Phase 3 trial results: 15-18% visceral fat reduction in HIV lipodystrophy, GHRH receptor mechanism, glucose effects, and durability data.

Peptides10 min read

Deep DiveMay 28, 2026

Tesamorelin for Visceral Fat: The Most Clinically Validated Fat Loss Peptide

Tesamorelin for visceral fat: FDA-approved GHRH analog with RCT data showing 15% VAT reduction in humans. Mechanism, dosing, and what the trials show.

Peptides8 min read

Deep DiveMay 28, 2026

Semaglutide

Semaglutide mechanism and clinical data: how this GLP-1 analog works across pancreas and brain, trial results in weight loss and diabetes, dosing protocols.

Peptides10 min read

Deep DiveMay 28, 2026

Semaglutide Half-Life: Why Once-Weekly Dosing Works

Semaglutide half-life explained: albumin binding and DPP-4 resistance create 165-hour circulation, enabling once-weekly GLP-1 receptor dosing.

Peptides10 min read

Deep DiveMay 28, 2026

How Peptides Promote Fat Loss: Mechanisms Across Compound Classes

How peptides promote fat loss: GHRH agonists vs. lipolytic fragments, mechanisms across tesamorelin and AOD-9604, and what human trials show.

Peptides11 min read

Deep DiveMay 28, 2026

How Does VIP Peptide Work? Anti-Inflammatory and Neuromodulatory Mechanisms

VIP peptide mechanism explained: VPAC receptor signaling, anti-inflammatory effects in rodent models, limited human data, and research dosing protocols.

Peptides8 min read

Deep DiveMay 28, 2026

How Does Sermorelin Work? GHRH Receptor Binding and GH Pulse Explained

Sermorelin mechanism explained: how GHRH receptor binding triggers GH pulses, what clinical studies show, and how it differs from direct GH administration.

Peptides7 min read

Deep DiveMay 28, 2026

CJC-1295 and Ipamorelin for Fat Loss: Growth Hormone Axis Evidence

CJC-1295 and ipamorelin for fat loss: GH axis mechanisms, rodent lipolysis data, absent human trials, and why pharmaceutical programs stopped.

Peptides10 min read

Deep DiveMay 28, 2026

BPC-157: Mechanism, Research Evidence, and Protocol Overview

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide derived from human gastric juice. This research overview covers its mechanism of action, published evidence, and research protocols.

Peptides8 min read

Deep DiveMay 28, 2026

AOD-9604 for Fat Loss: Growth Hormone Fragment Lipolytic Research

AOD-9604 mechanism and research: how this hGH fragment drives lipolysis without receptor binding, what human trials showed, and why it stalled.

Peptides9 min read

SARMs

1 article

Deep DiveMay 29, 2026

Cardarine (GW-501516): Research Summary and Risk Assessment

Cardarine (GW-501516) research summary: PPARδ mechanism, metabolic effects in trials, cancer findings that halted development, and evidence gaps.

SARMs7 min read

Compound Comparisons

3 articles

ComparisonMay 29, 2026

Epithalon vs epitalon

Epithalon vs epitalon explained: same tetrapeptide, different spellings. Evidence review, mechanism, replication gaps, and when the distinction matters.

Compound Comparisons7 min read

ComparisonMay 29, 2026

AOD-9604 vs Semaglutide for Fat Loss Research

AOD-9604 vs Semaglutide for fat loss research: mechanism, evidence quality, and when to choose targeted lipolysis over central appetite suppression.

Compound Comparisons8 min read

ComparisonMay 28, 2026

Tirzepatide vs Semaglutide: Which GLP-1 Agonist Has Better Evidence?

Tirzepatide vs semaglutide: head-to-head trial data, mechanistic differences, weight loss comparison, and when dual GIP/GLP-1 agonism justifies the trade-off.

Compound Comparisons9 min read

Research Guides

1 article

OverviewMay 28, 2026

Best Peptides for Fat Loss: An Evidence-Ranked Research Overview

Best peptides for fat loss ranked by evidence: Tesamorelin, CJC-1295, Ipamorelin, MK-677, and AOD-9604 mechanisms, human trials, and research gaps.

Research Guides10 min read

Protocols & Guides

5 articles

GuideMay 28, 2026

Tirzepatide Dosing Protocol: What the Clinical Trials Used

Tirzepatide dosing protocol from FDA trials: 4-week escalation schedule, reconstitution parameters, storage at 2-8°C, and variables that affect GI tolerance.

Protocols & Guides9 min read

GuideMay 28, 2026

Semaglutide Dosing Protocol: What STEP Trials Used

Semaglutide dosing protocol from STEP trials: 16-week escalation schedule, injection technique, storage requirements, and variables affecting research outcomes.

Protocols & Guides8 min read

GuideMay 28, 2026

Peptide protocol for weight loss

Peptide protocol for weight loss: GLP-1 agonist dosing, injection timing, storage requirements, and the variables that determine whether your research protoc...

Protocols & Guides9 min read

GuideMay 28, 2026

Peptide protocol for fat loss

Peptide fat loss protocols: research dosing for GH secretagogues, reconstitution steps, storage parameters, and variables affecting lipolysis outcomes.

Protocols & Guides9 min read

GuideMay 28, 2026

Best peptide for fat loss

Best peptide for fat loss: AOD-9604 and GH secretagogue protocols, practical dosing, reconstitution, and what the research actually shows.

Protocols & Guides8 min read

Research Q&A

3 articles

Q&AMay 29, 2026

Does Ipamorelin Actually Raise Growth Hormone? The Evidence

Does ipamorelin raise growth hormone? Yes, but only in pulses. What the rodent and human studies show, how GHS-R1a drives the effect, and what's still unknown.

Research Q&A8 min read

Q&AMay 29, 2026

Do you actually need a PCT after RAD-140? Confused by conflicting info

RAD-140 PCT requirements: what the human trial data shows about testosterone suppression, who needs post-cycle therapy, and how to decide based on bloodwork.

Research Q&A7 min read

Q&AMay 29, 2026

BPC-157 for gut/leaky gut healing — what dose and how long before seeing results?

BPC-157 for gut healing: rodent dosing, timeline to results, mechanism via VEGF signaling, and what human data actually exists (very little).

Research Q&A7 min read

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Medical disclaimerAll articles are for research and educational purposes only. Nothing constitutes medical advice, diagnosis, or treatment. Read full disclaimer